Top 10 Supplements For Longevity in 2026 (Science‑Backed + iHerb Picks)

Why Longevity Supplements Matter in 2026

Longevity isn’t just about living longer — it’s about living healthier for more years. As we age, our bodies undergo changes like lower cellular energy, reduced DNA repair, inflammation, and declining metabolism. Targeted supplements can help support these systems and slow biological aging.

Below are the top 10 longevity supplements supported by scientific research and trends in 2026, along with real iHerb products you can use to build your daily longevity routine.

🧠 1. NMN (Nicotinamide Mononucleotide) — Cellular Energy & NAD+ Support

NMN is a precursor to NAD+, a coenzyme that declines with age and is critical for cellular energy, DNA repair, and metabolism. Supporting NAD+ levels helps maintain vitality and healthy aging.

Best iHerb Picks:

ProHealth Longevity NMN Pro 300 – Boosts NAD+ levels for energy, metabolism, and cellular resilience.

ProHealth Longevity NAD+ Pro Powder – Flexibly dosed NMN powder for customizable stacks.

❤️ 2. NMN + CoQ10 Combo — Mitochondrial & Heart Health

Combining NMN with CoQ10 supports mitochondrial energy production — essential for longevity and muscle function as we age.

Best iHerb Pick:

ProHealth Longevity NADH + CoQ10 – Powerful combo for energy, heart, and metabolic support.

🧬 3. Resveratrol & Antioxidant Compounds

Resveratrol activates pathways linked to longevity and helps protect cells from oxidative stress — a major aging driver.

Best iHerb Picks:

ProHealth Longevity Trans‑Resveratrol Powder – High‑potency antioxidant to support cellular defense.

ProHealth Longevity Pterostilbene Pro – A resveratrol cousin with enhanced bioavailability.

🔥 4. Spermidine — Autophagy & Cellular Renewal

Spermidine is a natural compound that stimulates autophagy, your body’s internal system for clearing damaged cells — crucial for healthy aging.

Best iHerb Pick:

ProHealth Longevity Spermidine – Supports cellular cleanup and regeneration.

💪 5. Creatine — Muscle & Brain Longevity

Creatine is known for muscle support, but research also suggests benefits for cognitive health and long‑term functional aging — making it a smart longevity supplement.

Best iHerb Pick:

ProHealth Longevity Creatine – Clean formulation focused on energy and muscle preservation.

💊 6. Fisetin — Senolytic Cell Support

Fisetin helps clear out “senescent cells” — old cells that no longer divide and contribute to inflammation and age‑related decline.

Best iHerb Pick:

Fisetin Pro Longevity – Pure fisetin supplement for cellular turnover support.

⚖️ 7. TMG (Trimethylglycine) — Methylation & Metabolism

TMG supports healthy methylation pathways — vital for detoxification, DNA repair, and metabolic balance.

Best iHerb Picks:

ProHealth Longevity TMG Pro Powder – Supports methylation and metabolic health.

ProHealth Longevity TMG Pro 1000 mg – Higher‑strength option for daily methylation support.

🌿 8. Curcumin — Inflammation & Cellular Stress Fighter

Curcumin, the active compound in turmeric, helps calm inflammation — a central factor in aging.

Best iHerb Pick:

ProHealth Longevity Curcumine Optimisée – Bioavailable curcumin formulation.

🧬 9. Collagen & Structural Support

Collagen supports skin elasticity, joint health, and bone strength, which tend to decline with age.

Best iHerb Pick:

👉 Try collagen peptides with hyaluronic acid and vitamin C — foundational for connective tissue longevity.

🐟 10. Omega‑3 Fatty Acids — Brain & Heart Longevity

Omega‑3s help reduce chronic inflammation and support heart and brain health — key pillars of long healthspan.

Best iHerb Picks: fish oil or algal DHA/EPA blends in the anti‑aging & longevity category to support vascular and cognitive health.

How to Build Your Longevity Stack in 2026

Here’s a simple example stack you can follow:

• Daily: NMN + Omega‑3 + Curcumin

• 3–4×/week: Spermidine + Creatine

• Weekly: Fisetin + Resveratrol

Consistency is key — supplements support lifestyle, not replace healthy habits like good sleep, nutrition, movement, and stress management.

FAQs About Longevity Supplements

🔹 Do these supplements really work?Many longevity supplements are backed by research linking them to improved cellular function, energy metabolism, and reduced inflammation — but they’re most effective when combined with a healthy lifestyle.

🔹 How soon do you see results?Markers like energy and digestion may shift in weeks, while deeper cellular benefits show up over months with consistent use.

🔹 Should you cycle supplements?Yes — some like spermidine and fisetin may be used cyclically for optimal effects.